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Custom Isotope Labeling

Pharmacokinetic studies have traditionally used radiolabeled target compounds as a means for evaluating body absorption, distribution, metabolism and excretion (ADME). New analysis technologies now make it possible to use targets enriched with stable isotopes such as carbon-13 and deuterium as alternatives to radioisotopes. Whether one is interested in radioisotopes or stable isotopes, only a limited number and variety of isotopically enriched intermediates are readily available. The intermediates used in the synthesis route for your desired target compound may not exist as labeled compounds; thus, a whole new synthesis will be needed for incorporation of the isotope of interest. SRI is your complete source for isotopically labeled compounds of high purity and high isotopic enrichment, with specific labeling patterns in complex molecules and drugs for metabolism and biochemical studies.

Capabilities
SRI has more than 40 years of experience in the design and synthesis of complex drugs. Our radiochemists understand the requirements of labeling biologically active compounds so that pharmacologists, toxicologists and biochemists will have the tools needed for producing toxicological and pharmacokinetic data for new pharmaceuticals, chemicals and pesticides. We can

• Incorporate isotopic labels at specific positions of the compound, including double labeling and multiple site labeling schemes
• Prepare target compounds by biosynthesis, semisynthesis or total synthesis
• Handle multi-Curie amounts of ³H, ¹⁴C, ³²P, and other radioisotopes necessary for biological studies in our specially designed, environmentally sound, controlled-access facilities.
• Work together with pharmacokineticists, biochemical pharmacologists and mass spectrometrists in conducting ADME/PK and other biochemical studies. SRI has a specially designed and equipped laboratory facility for the synthesis of radiolabeled materials. We operate under a Radioactive Materials License that allows us to possess suitable quantities of radioisotopes, including ³H, ¹⁴C and others as needed. All products of custom radiosynthesis work are shipped according to NRC and DOT regulations.

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       Last Updated Mar 19, 2009